The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease

Medientyp: E-Artikel
Titel: The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease
Beteiligte: Peischard, Stefan; Ho, Huyen Tran; Piccini, Ilaria; Strutz-Seebohm, Nathalie; Röpke, Albrecht; Liashkovich, Ivan; Gosain, Hiteshika; Rieger, Bettina; Klingel, Karin; Eggers, Britta; Marcus, Katrin; Linke, Wolfgang A.; Müller, Frank Ulrich; Ludwig, Stephan; Greber, Boris; Busch, Karin; Seebohm, Guiscard
Erschienen: Springer Science and Business Media LLC, 2020
Erschienen in: Scientific Reports
Sprache: Englisch
DOI: 10.1038/s41598-020-72966-9
ISSN: 2045-2322
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>A detailed description of pathophysiological effects that viruses exert on their host is still challenging. For the first time, we report a highly controllable viral expression model based on an iPS-cell line from a healthy human donor. The established viral model system enables a dose-dependent and highly localized RNA-virus expression in a fully controllable environment, giving rise for new applications for the scientific community.</jats:p>
Zugangsstatus: Freier Zugang

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