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Masana, Lluís; Correig, Eudald; Ibarretxe, Daiana; Anoro, Eva; Arroyo, Juan Antonio; Jericó, Carlos; Guerrero, Carolina; Miret, Marcel·la; Näf, Silvia; Pardo, Anna; Perea, Verónica; Pérez-Bernalte, Rosa; Plana, Núria; Ramírez-Montesinos, Rafael; Royuela, Meritxell; Soler, Cristina; Urquizu-Padilla, Maria; Zamora, Alberto; Pedro-Botet, Juan; Rodríguez-Borjabad, Cèlia; Andreychuk, Natalia; Malo, Ana; Matas, Laia; del Señor Cortes-Fernandez, Maria; [...]

Low HDL and high triglycerides predict COVID-19 severity

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  • Medientyp: E-Artikel
  • Titel: Low HDL and high triglycerides predict COVID-19 severity
  • Beteiligte: Masana, Lluís; Correig, Eudald; Ibarretxe, Daiana; Anoro, Eva; Arroyo, Juan Antonio; Jericó, Carlos; Guerrero, Carolina; Miret, Marcel·la; Näf, Silvia; Pardo, Anna; Perea, Verónica; Pérez-Bernalte, Rosa; Plana, Núria; Ramírez-Montesinos, Rafael; Royuela, Meritxell; Soler, Cristina; Urquizu-Padilla, Maria; Zamora, Alberto; Pedro-Botet, Juan; Rodríguez-Borjabad, Cèlia; Andreychuk, Natalia; Malo, Ana; Matas, Laia; del Señor Cortes-Fernandez, Maria; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/s41598-021-86747-5
  • ISSN: 2045-2322
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.</jats:p>
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