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Rossi, Átila Duque; de Araújo, João Locke Ferreira; de Almeida, Tailah Bernardo; Ribeiro-Alves, Marcelo; de Almeida Velozo, Camila; Almeida, Jéssica Maciel de; de Carvalho Leitão, Isabela; Ferreira, Sâmila Natiane; da Silva Oliveira, Jéssica; Alves, Hugo José; Scheid, Helena Toledo; Faffe, Débora Souza; Galliez, Rafael Mello; de Ávila, Renata Eliane; Resende, Gustavo Gomes; Teixeira, Mauro Martins; Herlinger, Alice Laschuk; dos Santos Carvalho, Aliny; dos Santos, André Felipe Andrade; Castiñeiras, Anna Carla Pinto; Teixeira, Bianca Isabelle Barreto; da Silva, Bianca Ortiz; Clarkson, Bruno; Dematté, Bruno Eduardo; [...]

Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress

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  • Medientyp: E-Artikel
  • Titel: Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress
  • Beteiligte: Rossi, Átila Duque; de Araújo, João Locke Ferreira; de Almeida, Tailah Bernardo; Ribeiro-Alves, Marcelo; de Almeida Velozo, Camila; Almeida, Jéssica Maciel de; de Carvalho Leitão, Isabela; Ferreira, Sâmila Natiane; da Silva Oliveira, Jéssica; Alves, Hugo José; Scheid, Helena Toledo; Faffe, Débora Souza; Galliez, Rafael Mello; de Ávila, Renata Eliane; Resende, Gustavo Gomes; Teixeira, Mauro Martins; Herlinger, Alice Laschuk; dos Santos Carvalho, Aliny; dos Santos, André Felipe Andrade; Castiñeiras, Anna Carla Pinto; Teixeira, Bianca Isabelle Barreto; da Silva, Bianca Ortiz; Clarkson, Bruno; Dematté, Bruno Eduardo; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/s41598-021-88944-8
  • ISSN: 2045-2322
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>ACE2 and TMPRSS2 are key players on SARS-CoV-2 entry into host cells. However, it is still unclear whether expression levels of these factors could reflect disease severity. Here, a case–control study was conducted with 213 SARS-CoV-2 positive individuals where cases were defined as COVID-19 patients with respiratory distress requiring oxygen support (N = 38) and controls were those with mild to moderate symptoms of the disease who did not need oxygen therapy along the entire clinical course (N = 175). <jats:italic>ACE2</jats:italic> and <jats:italic>TMPRSS2</jats:italic> mRNA levels were evaluated in nasopharyngeal swab samples by RT-qPCR and logistic regression analyzes were applied to estimate associations with respiratory outcomes. <jats:italic>ACE2</jats:italic> and <jats:italic>TMPRSS2</jats:italic> levels positively correlated with age, which was also strongly associated with respiratory distress. Increased nasopharyngeal <jats:italic>ACE2</jats:italic> levels showed a protective effect against this outcome (<jats:sub>adj</jats:sub>OR = 0.30; 95% CI 0.09–0.91), while TMPRSS2/ACE2 ratio was associated with risk (<jats:sub>adj</jats:sub>OR = 4.28; 95% CI 1.36–13.48). On stepwise regression, TMPRSS2/ACE2 ratio outperformed <jats:italic>ACE2</jats:italic> to model COVID-19 severity. When nasopharyngeal swabs were compared to bronchoalveolar lavages in an independent cohort of COVID-19 patients under mechanical ventilation, similar expression levels of these genes were observed. These data suggest nasopharyngeal TMPRSS2/ACE2 as a promising candidate for further prediction models on COVID-19.</jats:p>
  • Zugangsstatus: Freier Zugang