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Tarnoki, Adam Domonkos; Tarnoki, David Laszlo; Oláh, Csaba; Szily, Marcell; Kovacs, Daniel T.; Dienes, András; Piroska, Marton; Forgo, Bianka; Pinheiro, Marina; Ferreira, Paulo; Kostyál, László; Meszaros, Martina; Pako, Judit; Kunos, Laszlo; Bikov, Andras

Lumbar spine abnormalities in patients with obstructive sleep apnoea

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  • Medientyp: E-Artikel
  • Titel: Lumbar spine abnormalities in patients with obstructive sleep apnoea
  • Beteiligte: Tarnoki, Adam Domonkos; Tarnoki, David Laszlo; Oláh, Csaba; Szily, Marcell; Kovacs, Daniel T.; Dienes, András; Piroska, Marton; Forgo, Bianka; Pinheiro, Marina; Ferreira, Paulo; Kostyál, László; Meszaros, Martina; Pako, Judit; Kunos, Laszlo; Bikov, Andras
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Scientific Reports, 11 (2021) 1
  • Sprache: Englisch
  • DOI: 10.1038/s41598-021-95667-3
  • ISSN: 2045-2322
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: AbstractPrevious studies suggested cervical spondylosis as a risk factor for development of obstructive sleep apnoea (OSA). We aimed to assess lumbar disc degeneration in patients with OSA and correlate the findings with symptoms and disease severity. Twenty-seven patients with OSA and 29 non-OSA controls underwent sleep studies and lumbar magnetic resonance imaging (MRI), and completed the Epworth Sleepiness Scale and the 24-item Roland‐Morris Disability Questionnaire (RMDQ) questionnaires. Plasma klotho was determined with enzyme-linked immunosorbent assay. Patients with OSA had higher number of disc bulges (4.6 ± 3.7 vs. 1.7 ± 2.5, p < 0.01) and anterior spondylophytes (2.7 ± 4.2 vs. 0.8 ± 2.1, p < 0.01), increased disc degeneration (total Pfirrmann score 16.7 ± 4.7 vs. 13.2 ± 4.1, p < 0.01) and vertebral fatty degeneration (7.8 ± 4.7 vs. 3.8 ± 3.7, p < 0.01). There was no difference in the RMDQ score (0/0–3.5/ vs. 0/0–1/, p > 0.05). Markers of OSA severity, including the oxygen desaturation index and percentage of total sleep time spent with saturation < 90% as well as plasma levels of klotho were correlated with the number of disc bulges and anterior spondylophytes (all p < 0.05). OSA is associated with lumbar spondylosis. Our study highlights the importance of lumbar imaging in patients with OSA reporting lower back pain.
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