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Liu, Liang; Takusagawa, Hana L.; Greenwald, Miles F.; Wang, Jie; Alonzo, Brock; Edmunds, Beth; Morrison, John C.; Tan, Ou; Jia, Yali; Huang, David

Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure

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  • Medientyp: E-Artikel
  • Titel: Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure
  • Beteiligte: Liu, Liang; Takusagawa, Hana L.; Greenwald, Miles F.; Wang, Jie; Alonzo, Brock; Edmunds, Beth; Morrison, John C.; Tan, Ou; Jia, Yali; Huang, David
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/s41598-021-96225-7
  • ISSN: 2045-2322
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>We investigated the time and location of retinal perfusion recovery after surgical intraocular pressure (IOP) lowering in glaucoma by using optical coherent tomography angiography (OCTA). Seventeen patients were analyzed. The 4.5 × 4.5-mm OCTA scans centered on the disc were performed preoperatively and postoperatively at 6 weeks, 3 months, and 6 months. The peripapillary retinal nerve fiber layer (NFL) thickness, NFL plexus capillary density (NFLP-CD) and visual field (VF) were measured overall and in 8 corresponding sectors. The low-perfusion area (LPA) was used to assess the cumulative area where local NFLP-CD was significantly below normal. At 6 months, the average IOP decreased 5.3 mmHg (<jats:italic>P</jats:italic> = 0.004), LPA decreased by 15% (<jats:italic>P</jats:italic> = 0.005), and NFLP-CD improved by 12% (<jats:italic>P</jats:italic> &lt; 0.001). The NFL thickness and VF mean deviation didn’t change significantly at any time point. Among the sectors with significant preoperative NFLP-CD loss, the recovery at 6 months was greatest in sectors with minimal preoperative NFL thinning (<jats:italic>P</jats:italic> &lt; 0.001). In conclusion, surgical IOP lowering may improve NFLP capillary perfusion after 6 months. The perfusion recovery tended to occur in areas with minimal NFL thinning at baseline. OCTA parameters may have potential usefulness as pharmacodynamic biomarkers for glaucoma therapy.</jats:p>
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