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Chacko, Anu; Delbaz, Ali; Walkden, Heidi; Basu, Souptik; Armitage, Charles W.; Eindorf, Tanja; Trim, Logan K.; Miller, Edith; West, Nicholas P.; St John, James A.; Beagley, Kenneth W.; Ekberg, Jenny A. K.

Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk

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  • Medientyp: E-Artikel
  • Titel: Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk
  • Beteiligte: Chacko, Anu; Delbaz, Ali; Walkden, Heidi; Basu, Souptik; Armitage, Charles W.; Eindorf, Tanja; Trim, Logan K.; Miller, Edith; West, Nicholas P.; St John, James A.; Beagley, Kenneth W.; Ekberg, Jenny A. K.
  • Erschienen: Springer Science and Business Media LLC, 2022
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/s41598-022-06749-9
  • ISSN: 2045-2322
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p><jats:italic>Chlamydia pneumoniae</jats:italic> is a respiratory tract pathogen but can also infect the central nervous system (CNS). Recently, the link between <jats:italic>C. pneumoniae</jats:italic> CNS infection and late-onset dementia has become increasingly evident. In mice, CNS infection has been shown to occur weeks to months after intranasal inoculation. By isolating live <jats:italic>C. pneumoniae</jats:italic> from tissues and using immunohistochemistry, we show that <jats:italic>C. pneumoniae</jats:italic> can infect the olfactory and trigeminal nerves, olfactory bulb and brain within 72 h in mice. <jats:italic>C. pneumoniae</jats:italic> infection also resulted in dysregulation of key pathways involved in Alzheimer’s disease pathogenesis at 7 and 28 days after inoculation. Interestingly, amyloid beta accumulations were also detected adjacent to the <jats:italic>C. pneumoniae</jats:italic> inclusions in the olfactory system. Furthermore, injury to the nasal epithelium resulted in increased peripheral nerve and olfactory bulb infection, but did not alter general CNS infection. In vitro,<jats:italic> C. pneumoniae</jats:italic> was able to infect peripheral nerve and CNS glia. In summary, the nerves extending between the nasal cavity and the brain constitute invasion paths by which <jats:italic>C. pneumoniae</jats:italic> can rapidly invade the CNS likely by surviving in glia and leading to Aβ deposition.</jats:p>
  • Zugangsstatus: Freier Zugang