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Carrat, Fabrice; Villarroel, Paola Mariela Saba; Lapidus, Nathanael; Fourié, Toscane; Blanché, Hélène; Dorival, Céline; Nicol, Jérôme; Deleuze, Jean-François; Robineau, Olivier; Carrat, Fabrice; Zins, Marie; Severi, Gianluca; Touvier, Mathilde; Blanché, Hélène; Deleuze, Jean-François; de Lamballerie, Xavier; Lusivika-Nzinga, Clovis; Pannetier, Gregory; Lapidus, Nathanael; Goderel, Isabelle; Dorival, Céline; Nicol, Jérôme; Robineau, Olivier; Kab, Sofiane; [...]

Heterogeneous SARS-CoV-2 humoral response after COVID-19 vaccination and/or infection in the general population

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  • Medientyp: E-Artikel
  • Titel: Heterogeneous SARS-CoV-2 humoral response after COVID-19 vaccination and/or infection in the general population
  • Beteiligte: Carrat, Fabrice; Villarroel, Paola Mariela Saba; Lapidus, Nathanael; Fourié, Toscane; Blanché, Hélène; Dorival, Céline; Nicol, Jérôme; Deleuze, Jean-François; Robineau, Olivier; Carrat, Fabrice; Zins, Marie; Severi, Gianluca; Touvier, Mathilde; Blanché, Hélène; Deleuze, Jean-François; de Lamballerie, Xavier; Lusivika-Nzinga, Clovis; Pannetier, Gregory; Lapidus, Nathanael; Goderel, Isabelle; Dorival, Céline; Nicol, Jérôme; Robineau, Olivier; Kab, Sofiane; [...]
  • Erschienen: Springer Science and Business Media LLC, 2022
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/s41598-022-11787-4
  • ISSN: 2045-2322
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Assessment of the intensity, dynamics and determinants of the antibody response after SARS-CoV-2 infection or vaccination in the general population is critical to guide vaccination policies. This study characterized the anti-spike IgG titers in 13,971 participants included in a French multicohort population-based serological survey on COVID-19 between April and October 2020 and followed-up with serological testing between May and October 2021. Eight follow-up profiles were defined depending on SARS-CoV-2 infection (0, 1 or 2) and COVID-19 vaccination (0, 1, 2 or 3). The anti-spike titer was lower in adults with no vaccination even in case of infection or reinfection, while it was higher in adults with infection followed by vaccination. The anti-spike titer was negatively correlated with age in vaccinated but uninfected adults, whereas it was positively correlated with age in unvaccinated but infected adults. In adults with 2 vaccine injections and no infection, the vaccine protocol, age, gender, and time since the last vaccine injection were independently associated with the anti-spike titer. The decrease in anti-spike titer was much more rapid in vaccinated than in infected subjects. These results highlight the strong heterogeneity of the antibody response against SARS-CoV-2 in the general population depending on previous infection and vaccination.</jats:p>
  • Zugangsstatus: Freier Zugang