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Opel, Nils; Thalamuthu, Anbupalam; Milaneschi, Yuri; Grotegerd, Dominik; Flint, Claas; Leenings, Ramona; Goltermann, Janik; Richter, Maike; Hahn, Tim; Woditsch, Georg; Berger, Klaus; Hermesdorf, Marco; McIntosh, Andrew; Whalley, Heather C.; Harris, Mathew A.; MacMaster, Frank P.; Walter, Henrik; Veer, Ilya M.; Frodl, Thomas; Carballedo, Angela; Krug, Axel; Nenadic, Igor; Kircher, Tilo; Aleman, Andre; [...]

Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders

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  • Medientyp: E-Artikel
  • Titel: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders : Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group
  • Beteiligte: Opel, Nils; Thalamuthu, Anbupalam; Milaneschi, Yuri; Grotegerd, Dominik; Flint, Claas; Leenings, Ramona; Goltermann, Janik; Richter, Maike; Hahn, Tim; Woditsch, Georg; Berger, Klaus; Hermesdorf, Marco; McIntosh, Andrew; Whalley, Heather C.; Harris, Mathew A.; MacMaster, Frank P.; Walter, Henrik; Veer, Ilya M.; Frodl, Thomas; Carballedo, Angela; Krug, Axel; Nenadic, Igor; Kircher, Tilo; Aleman, Andre; [...]
  • Erschienen: Springer Science and Business Media LLC, 2021
  • Erschienen in: Molecular Psychiatry
  • Sprache: Englisch
  • DOI: 10.1038/s41380-020-0774-9
  • ISSN: 1359-4184; 1476-5578
  • Entstehung:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (<jats:italic>n</jats:italic> = 6420) and genetic data (<jats:italic>n</jats:italic> = 3907) from the ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI &gt; 30) was significantly associated with cortical and subcortical abnormalities in both mass-univariate and multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found for associations between obesity and lower temporo-frontal cortical thickness (maximum Cohen´s <jats:italic>d</jats:italic> (left fusiform gyrus) = −0.33). The observed regional distribution and effect size of cortical thickness reductions in obesity revealed considerable similarities with corresponding patterns of lower cortical thickness in previously published studies of neuropsychiatric disorders. A higher polygenic risk score for obesity significantly correlated with lower occipital surface area. In addition, a significant age-by-obesity interaction on cortical thickness emerged driven by lower thickness in older participants. Our findings suggest a neurobiological interaction between obesity and brain structure under physiological and pathological brain conditions.</jats:p>