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Plavén-Sigray, Pontus; Ikonen Victorsson, Pauliina; Santillo, Alexander; Matheson, Granville J.; Lee, Maria; Collste, Karin; Fatouros-Bergman, Helena; Sellgren, Carl M.; Erhardt, Sophie; Agartz, Ingrid; Halldin, Christer; Farde, Lars; Cervenka, Simon

Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis

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  • Medientyp: E-Artikel
  • Titel: Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis
  • Beteiligte: Plavén-Sigray, Pontus; Ikonen Victorsson, Pauliina; Santillo, Alexander; Matheson, Granville J.; Lee, Maria; Collste, Karin; Fatouros-Bergman, Helena; Sellgren, Carl M.; Erhardt, Sophie; Agartz, Ingrid; Halldin, Christer; Farde, Lars; Cervenka, Simon
  • Erschienen: Springer Science and Business Media LLC, 2022
  • Erschienen in: Molecular Psychiatry
  • Sprache: Englisch
  • DOI: 10.1038/s41380-021-01349-x
  • ISSN: 1359-4184; 1476-5578
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Pharmacological and genetic evidence support a role for an involvement of the dopamine D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging studies have suggested lower levels of D2-R in thalamus, but results are inconclusive. The objective of the present study was to use improved methodology to compare D2-R density in whole thalamus and thalamic subregions between first-episode psychosis patients and healthy controls. Differences in thalamocortical connectivity was explored based on the D2-R results. 19 antipsychotic-naive first-episode psychosis patients and 19 age- and sex-matched healthy controls were examined using high-resolution Positron Emission Tomography (PET) and the high-affinity D2-R radioligand [<jats:sup>11</jats:sup>C]FLB457. The main outcome was D2-R binding potential (BP<jats:sub>ND</jats:sub>) in thalamus, and it was predicted that patients would have lower binding. Diffusion tensor imaging (DTI) was performed in a subgroup of 11 patients and 15 controls. D2-R binding in whole thalamus was lower in patients compared with controls (Cohen’s dz = −0.479, <jats:italic>p</jats:italic> = 0.026, Bayes Factor (BF) &gt; 4). Among subregions, lower BP<jats:sub>ND</jats:sub> was observed in the ROI representing thalamic connectivity to the frontal cortex (Cohen’s dz = −0.527, <jats:italic>p</jats:italic> = 0.017, BF &gt; 6). A meta-analysis, including the sample of this study, confirmed significantly lower thalamic D2-R availability in patients. Exploratory analyses suggested that patients had lower fractional anisotropy values compared with controls (Cohen’s <jats:italic>d</jats:italic> = −0.692, <jats:italic>p</jats:italic> = 0.036) in the inferior thalamic radiation. The findings support the hypothesis of a dysregulation of thalamic dopaminergic neurotransmission in schizophrenia, and it is hypothesized that this could underlie a disturbance of thalamocortical connectivity.</jats:p>