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Korzeniewski, Steven J.; Allred, Elizabeth N.; O’Shea, T. Michael; Leviton, Alan; Kuban, Karl C. K.; Lee, Kathleen; McGovern, Anne; Gambardella, Jill; Ursprung, Susan; Ecklund, Ruth Blomquist Kristen; Bassan, Haim; Butler, Samantha; Duplessis, Adré; Hahn, Cecil; Limperopoulos, Catherine; Khwaja, Omar; Soul, Janet S.; Shah, Bhavesh; Christianson, Karen; Hampf, Frederick; Gilmore, Herbert; McQuiston, Susan; Martin, Camilia R.; Hallisey, Colleen; [...]

Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation

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  • Medientyp: E-Artikel
  • Titel: Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation
  • Beteiligte: Korzeniewski, Steven J.; Allred, Elizabeth N.; O’Shea, T. Michael; Leviton, Alan; Kuban, Karl C. K.; Lee, Kathleen; McGovern, Anne; Gambardella, Jill; Ursprung, Susan; Ecklund, Ruth Blomquist Kristen; Bassan, Haim; Butler, Samantha; Duplessis, Adré; Hahn, Cecil; Limperopoulos, Catherine; Khwaja, Omar; Soul, Janet S.; Shah, Bhavesh; Christianson, Karen; Hampf, Frederick; Gilmore, Herbert; McQuiston, Susan; Martin, Camilia R.; Hallisey, Colleen; [...]
  • Erschienen: Springer Science and Business Media LLC, 2018
  • Erschienen in: Translational Psychiatry
  • Sprache: Englisch
  • DOI: 10.1038/s41398-018-0156-0
  • ISSN: 2158-3188
  • Schlagwörter: Biological Psychiatry ; Cellular and Molecular Neuroscience ; Psychiatry and Mental health
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Among the 1 of 10 children who are born preterm annually in the United States, 6% are born before the third trimester. Among children who survive birth before the 28th week of gestation, the risks of autism spectrum disorder (ASD) and non-autistic social impairment are severalfold higher than in the general population. We examined the relationship between top quartile inflammation-related protein concentrations among children born extremely preterm and ASD or, separately, a high score on the Social Responsiveness Scale (SRS total score ≥65) among those who did not meet ASD criteria, using information only from the subset of children whose DAS-II verbal or non-verbal IQ was ≥70, who were assessed for ASD, and who had proteins measured in blood collected on ≥2 days (<jats:italic>N</jats:italic> = 763). ASD (<jats:italic>N</jats:italic> = 36) assessed at age 10 years is associated with recurrent top quartile concentrations of inflammation-related proteins during the first post-natal month (e.g., SAA odds ratio (OR); 95% confidence interval (CI): 2.5; 1.2–5.3) and IL-6 (OR; 95% CI: 2.6; 1.03–6.4)). Top quartile concentrations of neurotrophic proteins appear to moderate the increased risk of ASD associated with repeated top quartile concentrations of inflammation-related proteins. High (top quartile) concentrations of SAA are associated with elevated risk of ASD (2.8; 1.2–6.7) when Ang-1 concentrations are below the top quartile, but not when Ang-1 concentrations are high (1.3; 0.3–5.8). Similarly, high concentrations of TNF-α are associated with heightened risk of SRS-defined social impairment (<jats:italic>N</jats:italic> = 130) (2.0; 1.1–3.8) when ANG-1 concentrations are not high, but not when ANG-1 concentrations are elevated (0.5; 0.1–4.2).</jats:p>
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