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Oleaga, Carlota; Bernabini, Catia; Smith, Alec S.T.; Srinivasan, Balaji; Jackson, Max; McLamb, William; Platt, Vivien; Bridges, Richard; Cai, Yunqing; Santhanam, Navaneetha; Berry, Bonnie; Najjar, Sarah; Akanda, Nesar; Guo, Xiufang; Martin, Candace; Ekman, Gail; Esch, Mandy B.; Langer, Jessica; Ouedraogo, Gladys; Cotovio, Jose; Breton, Lionel; Shuler, Michael L.; Hickman, James J.

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

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  • Medientyp: E-Artikel
  • Titel: Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs
  • Beteiligte: Oleaga, Carlota; Bernabini, Catia; Smith, Alec S.T.; Srinivasan, Balaji; Jackson, Max; McLamb, William; Platt, Vivien; Bridges, Richard; Cai, Yunqing; Santhanam, Navaneetha; Berry, Bonnie; Najjar, Sarah; Akanda, Nesar; Guo, Xiufang; Martin, Candace; Ekman, Gail; Esch, Mandy B.; Langer, Jessica; Ouedraogo, Gladys; Cotovio, Jose; Breton, Lionel; Shuler, Michael L.; Hickman, James J.
  • Erschienen: Springer Science and Business Media LLC, 2016
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/srep20030
  • ISSN: 2045-2322
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>We report on a functional human model to evaluate multi-organ toxicity in a 4-organ system under continuous flow conditions in a serum-free defined medium utilizing a pumpless platform for 14 days. Computer simulations of the platform established flow rates and resultant shear stress within accepted ranges. Viability of the system was demonstrated for 14 days as well as functional activity of cardiac, muscle, neuronal and liver modules. The pharmacological relevance of the integrated modules were evaluated for their response at 7 days to 5 drugs with known side effects after a 48 hour drug treatment regime. The results of all drug treatments were in general agreement with published toxicity results from human and animal data. The presented phenotypic culture model exhibits a multi-organ toxicity response, representing the next generation of <jats:italic>in vitro</jats:italic> systems and constitutes a step towards an <jats:italic>in vitro</jats:italic> “human-on-a-chip” assay for systemic toxicity screening.</jats:p>
  • Zugangsstatus: Freier Zugang