Erschienen:
Royal Society of Chemistry (RSC), 2016
Erschienen in:RSC Advances
Sprache:
Englisch
DOI:
10.1039/c6ra19197e
ISSN:
2046-2069
Entstehung:
Anmerkungen:
Beschreibung:
<p>The oxidation reaction of allopurinol to its active metabolite (oxypurinol) is investigated using the AO and P450 enzymes. To the contrary of AO (and XO), the P450 enzyme can metabolize the allopurinol with a not self-inhibitory mechanism.</p>