Racemization-free and scalable amidation of l-proline in organic media using ammonia and a biocatalyst only

Medientyp: E-Artikel
Titel: Racemization-free and scalable amidation of l-proline in organic media using ammonia and a biocatalyst only
Beteiligte: Pitzer, Julia; Steiner, Kerstin; Schmid, Christian; Schein, Viktor K.; Prause, Christoph; Kniely, Claudia; Reif, Michaela; Geier, Martina; Pietrich, Elena; Reiter, Tamara; Selig, Philipp; Stückler, Clemens; Pöchlauer, Peter; Steinkellner, Georg; Gruber, Karl; Schwab, Helmut; Glieder, Anton; Kroutil, Wolfgang
Erschienen: Royal Society of Chemistry (RSC), 2022
Erschienen in: Green Chemistry
Sprache: Englisch
DOI: 10.1039/d2gc00783e
ISSN: 1463-9262; 1463-9270
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Beschreibung: <jats:p>This work describes the biocatalytic amidation of <jats:sc>l</jats:sc>-proline with ammonia, resulting in a process with optimized atom efficiency giving prolinamide in an optically pure form (ee >99%). Detailed enzyme and reaction engineering studies are provided.</jats:p>

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