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Medientyp:
E-Artikel
Titel:
The Phage Shock Protein Response
Beteiligte:
Flores-Kim, Josué;
Darwin, Andrew J.
Erschienen:
Annual Reviews, 2016
Erschienen in:
Annual Review of Microbiology, 70 (2016) 1, Seite 83-101
Sprache:
Englisch
DOI:
10.1146/annurev-micro-102215-095359
ISSN:
0066-4227;
1545-3251
Entstehung:
Anmerkungen:
Beschreibung:
The phage shock protein (Psp) system was identified as a response to phage infection in Escherichia coli, but rather than being a specific response to a phage, it detects and mitigates various problems that could increase inner-membrane (IM) permeability. Interest in the Psp system has increased significantly in recent years due to appreciation that Psp-like proteins are found in all three domains of life and because the bacterial Psp response has been linked to virulence and other important phenotypes. In this article, we summarize our current understanding of what the Psp system detects and how it detects it, how four core Psp proteins form a signal transduction cascade between the IM and the cytoplasm, and current ideas that explain how the Psp response keeps bacterial cells alive. Although recent studies have significantly improved our understanding of this system, it is an understanding that is still far from complete.