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Medientyp:
E-Artikel
Titel:
Myelin Plasticity and Nervous System Function
Beteiligte:
Monje, Michelle
Erschienen:
Annual Reviews, 2018
Erschienen in:Annual Review of Neuroscience
Sprache:
Englisch
DOI:
10.1146/annurev-neuro-080317-061853
ISSN:
0147-006X;
1545-4126
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p> Structural plasticity in the myelinated infrastructure of the nervous system has come to light. Although an innate program of myelin development proceeds independent of nervous system activity, a second mode of myelination exists in which activity-dependent, plastic changes in myelin-forming cells influence myelin structure and neurological function. These complementary and possibly temporally overlapping activity-independent and activity-dependent modes of myelination crystallize in a model of experience-modulated myelin development and plasticity with broad implications for neurological function. In this article, I consider the contributions of myelin to neural circuit function, the dynamic influences of experience on myelin microstructure, and the role that plasticity of myelin may play in cognition. </jats:p>