Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Toward an Integrative Theory of Thalamic Function
Beteiligte:
Rikhye, Rajeev V.;
Wimmer, Ralf D.;
Halassa, Michael M.
Erschienen:
Annual Reviews, 2018
Erschienen in:Annual Review of Neuroscience
Sprache:
Englisch
DOI:
10.1146/annurev-neuro-080317-062144
ISSN:
0147-006X;
1545-4126
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>The thalamus has long been suspected to have an important role in cognition, yet recent theories have favored a more corticocentric view. According to this view, the thalamus is an excitatory feedforward relay to or between cortical regions, and cognitively relevant computations are exclusively cortical. Here, we review anatomical, physiological, and behavioral studies along evolutionary and theoretical dimensions, arguing for essential and unique thalamic computations in cognition. Considering their architectural features as well as their ability to initiate, sustain, and switch cortical activity, thalamic circuits appear uniquely suited for computing contextual signals that rapidly reconfigure task-relevant cortical representations. We introduce a framework that formalizes this notion, show its consistency with several findings, and discuss its prediction of thalamic roles in perceptual inference and behavioral flexibility. Overall, our framework emphasizes an expanded view of the thalamus in cognitive computations and provides a roadmap to test several of its theoretical and experimental predictions.</jats:p>