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Medientyp:
E-Artikel
Titel:
Neural Signaling in Cancer
Beteiligte:
Keough, Michael B.;
Monje, Michelle
Erschienen:
Annual Reviews, 2022
Erschienen in:Annual Review of Neuroscience
Sprache:
Englisch
DOI:
10.1146/annurev-neuro-111020-092702
ISSN:
1545-4126;
0147-006X
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p> Nervous system activity regulates development, homeostasis, and plasticity of the brain as well as other organs in the body. These mechanisms are subverted in cancer to propel malignant growth. In turn, cancers modulate neural structure and function to augment growth-promoting neural signaling in the tumor microenvironment. Approaching cancer biology from a neuroscience perspective will elucidate new therapeutic strategies for presently lethal forms of cancer. In this review, we highlight the neural signaling mechanisms recapitulated in primary brain tumors, brain metastases, and solid tumors throughout the body that regulate cancer progression. </jats:p>