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Medientyp:
E-Artikel
Titel:
Revelations About Aging and Disease from Unconventional Vertebrate Model Organisms
Beteiligte:
Zhao, Yang;
Seluanov, Andrei;
Gorbunova, Vera
Erschienen:
Annual Reviews, 2021
Erschienen in:
Annual Review of Genetics, 55 (2021) 1, Seite 135-159
Sprache:
Englisch
DOI:
10.1146/annurev-genet-071719-021009
ISSN:
1545-2948;
0066-4197
Entstehung:
Anmerkungen:
Beschreibung:
Aging is a major risk factor for multiple diseases. Understanding the underlying mechanisms of aging would help to delay and prevent age-associated diseases. Short-lived model organisms have been extensively used to study the mechanisms of aging. However, these short-lived species may be missing the longevity mechanisms that are needed to extend the lifespan of an already long-lived species such as humans. Unconventional long-lived animal species are an excellent resource to uncover novel mechanisms of longevity and disease resistance. Here, we review mechanisms that evolved in nonmodel vertebrate species to counteract age-associated diseases. Some antiaging mechanisms are conserved across species; however, various nonmodel species also evolved unique mechanisms to delay aging and prevent disease. This variety of antiaging mechanisms has evolved due to the remarkably diverse habitats and behaviors of these species. We propose that exploring a wider range of unconventional vertebrates will provide important resources to study antiaging mechanisms that are potentially applicable to humans.