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Medientyp:
E-Artikel
Titel:
Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils
Beteiligte:
Ng, Lai Guan;
Liu, Zhaoyuan;
Kwok, Immanuel;
Ginhoux, Florent
Erschienen:
Annual Reviews, 2023
Erschienen in:
Annual Review of Immunology, 41 (2023) 1, Seite 375-404
Sprache:
Englisch
DOI:
10.1146/annurev-immunol-081022-113627
ISSN:
0732-0582;
1545-3278
Entstehung:
Anmerkungen:
Beschreibung:
Myeloid cells are a significant proportion of leukocytes within tissues, comprising granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various myeloid cells that perform separate but complementary functions during homeostasis and disease, our understanding of tissue myeloid cells has evolved significantly. Exciting findings from transcriptomics profiling and fate-mapping mouse models have facilitated the identification of their developmental origins, maturation, and tissue-specific specializations. This review highlights the current understanding of tissue myeloid cells and the contributing factors of functional heterogeneity to better comprehend the complex and dynamic immune interactions within the healthy or inflamed tissue. Specifically, we discuss the new understanding of the contributions of granulocyte-monocyte progenitor–derived phagocytes to tissue myeloid cell heterogeneity as well as the impact of niche-specific factors on monocyte and neutrophil phenotype and function. Lastly, we explore the developing paradigm of myeloid cell heterogeneity during inflammation and disease.