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Medientyp:
E-Artikel
Titel:
P-Type ATPases
Beteiligte:
Palmgren, Michael G.;
Nissen, Poul
Erschienen:
Annual Reviews, 2011
Erschienen in:Annual Review of Biophysics
Sprache:
Englisch
DOI:
10.1146/annurev.biophys.093008.131331
ISSN:
1936-1238;
1936-122X
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p> P-type ATPases form a large superfamily of cation and lipid pumps. They are remarkably simple with only a single catalytic subunit and carry out large domain motions during transport. The atomic structure of P-type ATPases in different conformations, together with ample mutagenesis evidence, has provided detailed insights into the pumping mechanism by these biological nanomachines. Phylogenetically, P-type ATPases are divided into five subfamilies, P1–P5. These subfamilies differ with respect to transported ligands and the way they are regulated. </jats:p>