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Medientyp:
E-Artikel
Titel:
Effects of clenbuterol on insulin resistance in conscious obese Zucker rats
Beteiligte:
Pan, Shujia J.;
Hancock, Joe;
Ding, Zhenping;
Fogt, Donovan;
Lee, Mancheong;
Ivy, John L.
Erschienen:
American Physiological Society, 2001
Erschienen in:
American Journal of Physiology-Endocrinology and Metabolism, 280 (2001) 4, Seite E554-E561
Sprache:
Englisch
DOI:
10.1152/ajpendo.2001.280.4.e554
ISSN:
0193-1849;
1522-1555
Entstehung:
Anmerkungen:
Beschreibung:
The present study was conducted to determine the effect of chronic administration of the long-acting β2-adrenergic agonist clenbuterol on rats that are genetically prone to insulin resistance and impaired glucose tolerance. Obese Zucker rats ( fa/fa) were given 1 mg/kg of clenbuterol by oral intubation daily for 5 wk. Controls received an equivalent volume of water according to the same schedule. At the end of the treatment, rats were catheterized for euglycemic-hyperinsulinemic (15 mU insulin · kg−1· min−1) clamping. Clenbuterol did not change body weight compared with the control group but caused a redistribution of body weight: leg muscle weights increased, and abdominal fat weight decreased. The glucose infusion rate needed to maintain euglycemia and the rate of glucose disappearance were greater in the clenbuterol-treated rats. Furthermore, plasma insulin levels were decreased, and the rate of glucose uptake into hindlimb muscles and abdominal fat was increased in the clenbuterol-treated rats. This increased rate of glucose uptake was accompanied by a parallel increase in the rate of glycogen synthesis. The increase in muscle glucose uptake could not be ascribed to an increase in the glucose transport protein GLUT-4 in clenbuterol-treated rats. We conclude that chronic clenbuterol treatment reduces the insulin resistance of the obese Zucker rat by increasing insulin-stimulated muscle and adipose tissue glucose uptake. The improvements noted may be related to the repartitioning of body weight between tissues.