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Medientyp:
E-Artikel
Titel:
Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice
Beteiligte:
Comelli, Martina;
Meo, Marianna;
Cervantes, Daniel O.;
Pizzo, Emanuele;
Plosker, Aaron;
Mohler, Peter J.;
Hund, Thomas J.;
Jacobson, Jason T.;
Meste, Olivier;
Rota, Marcello
Erschienen:
American Physiological Society, 2020
Erschienen in:American Journal of Physiology-Heart and Circulatory Physiology
Sprache:
Englisch
DOI:
10.1152/ajpheart.00379.2020
ISSN:
0363-6135;
1522-1539
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p> We have investigated age-associated alterations of heart rate properties in mice using conscious electrocardiographic recordings. Our findings support the notion that aging is coupled with altered sympathovagal balance with consequences on heart rate variability. Moreover, by using a genetically engineered mouse line, we provide evidence that sodium channels modulate heart rate and its age-related adaptations. </jats:p>