Erschienen in:
American Journal of Physiology-Heart and Circulatory Physiology, 322 (2022) 3, Seite H373-H385
Sprache:
Englisch
DOI:
10.1152/ajpheart.00534.2021
ISSN:
0363-6135;
1522-1539
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p> We developed a novel setup allowing precise control of preload of EHT and characterized effects of the myosin activator OM. OM not only exerted contraction-slowing and positive inotropic effects but also increased diastolic tension. Effect size and direction varied between species, auxotonic and isometric conditions, concentration, and time. We also observed OM-induced increase of mitochondrial ROS, which has not been observed before and may explain part of the effects on contractility. </jats:p>