Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Increased arterial load alters aortic structural and functional properties during embryogenesis
Beteiligte:
Lucitti, Jennifer L.;
Visconti, Richard;
Novak, Jacqueline;
Keller, Bradley B.
Erschienen:
American Physiological Society, 2006
Erschienen in:
American Journal of Physiology-Heart and Circulatory Physiology, 291 (2006) 4, Seite H1919-H1926
Sprache:
Englisch
DOI:
10.1152/ajpheart.01061.2005
ISSN:
0363-6135;
1522-1539
Entstehung:
Anmerkungen:
Beschreibung:
As in the adult dorsal aorta, the embryonic dorsal aorta is an important determinant of cardiovascular function, and increased stiffness may have secondary effects on cardiac and microcirculatory development. We previously showed that acutely and chronically increased arterial load via vitelline artery ligation (VAL) increases systemic arterial stiffness. To test the hypothesis that local dorsal aortic stiffness also increases, we measured aortic pulse-wave velocity (PWV) and assessed the active and passive properties (stress and strain) of isolated aortic segments. PWV along the dorsal aorta increased acutely and chronically after VAL. Analysis of isolated aortic active properties suggests that load-exposed aortas experienced higher stress, but not strain, at similar intraluminal pressures. When smooth muscle tone was relaxed, strain decreased in VAL vessels, whereas stress became similar to control vessels. Immunohistochemical analysis revealed that although aortic smooth muscle α-actin content was similar between groups, more cell layers expressed smooth muscle α-actin, and myocyte cell shape was markedly rounder in VAL embryos. Additionally, aortic and perivascular collagen type I and III content significantly increased in load-exposed VAL vessels. Increased production of these proteins is consistent with the observed increase in aortic PWV and decreased strain in VAL passive aortic segments. Thus the embryonic dorsal aorta is sensitive to increased arterial load and adapts by altering its material properties via changes in collagen content.