Erschienen in:American Journal of Physiology-Lung Cellular and Molecular Physiology
Sprache:
Englisch
DOI:
10.1152/ajplung.00125.2023
ISSN:
1522-1504;
1040-0605
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p> An “obesity paradox” is discussed for pulmonary diseases. By linking lung proteome analyses to pulmonary structure and function, we demonstrate that diet-induced obesity affects lung adaptation to chronic hypoxia in various ways. The observed changes include not only adverse but also protective effects and are associated with altered abundances of vascular and extracellular matrix proteins. These results highlight the existence of relevant differences in individuals with obesity that may influence the pathogenesis of lung diseases. </jats:p>