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Medientyp:
E-Artikel
Titel:
Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse
Beteiligte:
Allen, David L.;
Harrison, Brooke C.;
Maass, Alexander;
Bell, Matthew L.;
Byrnes, William C.;
Leinwand, Leslie A.
Erschienen:
American Physiological Society, 2001
Erschienen in:Journal of Applied Physiology
Sprache:
Englisch
DOI:
10.1152/jappl.2001.90.5.1900
ISSN:
8750-7587;
1522-1601
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>In this paper, we describe the effects of voluntary cage wheel exercise on mouse cardiac and skeletal muscle. Inbred male C57/Bl6 mice (age 8–10 wk; n = 12) ran an average of 4.3 h/24 h, for an average distance of 6.8 km/24 h, and at an average speed of 26.4 m/min. A significant increase in the ratio of heart mass to body mass (mg/g) was evident after 2 wk of voluntary exercise, and cardiac atrial natriuretic factor and brain natriuretic peptide mRNA levels were significantly increased in the ventricles after 4 wk of voluntary exercise. A significant increase in the percentage of fibers expressing myosin heavy chain (MHC) IIa was observed in both the gastrocnemius and the tibialis anterior (TA) by 2 wk, and a significant decrease in the percentage of fibers expressing IIb MHC was evident in both muscles after 4 wk of voluntary exercise. The TA muscle showed a greater increase in the percentage of IIa MHC-expressing fibers than did the gastrocnemius muscle (40 and 20%, respectively, compared with 10% for nonexercised). Finally, the number of oxidative fibers as revealed by NADH-tetrazolium reductase histochemical staining was increased in the TA but not the gastrocnemius after 4 wk of voluntary exercise. All results are relative to age-matched mice housed without access to running wheels. Together these data demonstrate that voluntary exercise in mice results in cardiac and skeletal muscle adaptations consistent with endurance exercise.</jats:p>