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Medientyp:
E-Artikel
Titel:
Heat Shock Proteins and Cardiovascular Pathophysiology
Beteiligte:
Snoeckx, Luc H. E. H.;
Cornelussen, Richard N.;
Van Nieuwenhoven, Frans A.;
Reneman, Robert S.;
Van der Vusse, Ger J.
Erschienen:
American Physiological Society, 2001
Erschienen in:
Physiological Reviews, 81 (2001) 4, Seite 1461-1497
Sprache:
Englisch
DOI:
10.1152/physrev.2001.81.4.1461
ISSN:
0031-9333;
1522-1210
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>In the eukaryotic cell an intrinsic mechanism is present providing the ability to defend itself against external stressors from various sources. This defense mechanism probably evolved from the presence of a group of chaperones, playing a crucial role in governing proper protein assembly, folding, and transport. Upregulation of the synthesis of a number of these proteins upon environmental stress establishes a unique defense system to maintain cellular protein homeostasis and to ensure survival of the cell. In the cardiovascular system this enhanced protein synthesis leads to a transient but powerful increase in tolerance to such endangering situations as ischemia, hypoxia, oxidative injury, and endotoxemia. These so-called heat shock proteins interfere with several physiological processes within several cell organelles and, for proper functioning, are translocated to different compartments following stress-induced synthesis. In this review we describe the physiological role of heat shock proteins and discuss their protective potential against various stress agents in the cardiovascular system.</jats:p>