Erschienen in:
BioMed Research International, 2014 (2014), Seite 1-10
Sprache:
Englisch
DOI:
10.1155/2014/743812
ISSN:
2314-6133;
2314-6141
Entstehung:
Anmerkungen:
Beschreibung:
A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungusGanoderma applanatum(GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect. The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/mL) may exhibit selective activity against tumor cells (cell lines SiHa) and stimulate production of TNF-αTHP-1-derived macrophages at the level of 752.17 pg/mL. The GpEPS showed antibacterial properties againstStaphyloccoccus aureusand a toxic effect againstVibrio fischericells (82.8% cell damage). High cholesterol-binding capacity and triglycerides-binding capacity (57.9% and 41.6% after 24 h of incubation with the tested substances, resp.) were also detected for the investigated samples of GpEPS.