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Albrecht, Thomas; Zhang, Shiqi; Braun, Jana D.; Xia, Li; Rodriquez, Angelica; Qiu, Jiedong; Peters, Verena; Schmitt, Claus P.; Born, Jacob van den; Bakker, Stephan J. L.; Lammert, Alexander; Köppel, Hannes; Schnuelle, Peter; Krämer, Bernhard K.; Yard, Benito A.; Hauske, Sibylle J.

The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration

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  • Medientyp: E-Artikel
  • Titel: The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration
  • Beteiligte: Albrecht, Thomas; Zhang, Shiqi; Braun, Jana D.; Xia, Li; Rodriquez, Angelica; Qiu, Jiedong; Peters, Verena; Schmitt, Claus P.; Born, Jacob van den; Bakker, Stephan J. L.; Lammert, Alexander; Köppel, Hannes; Schnuelle, Peter; Krämer, Bernhard K.; Yard, Benito A.; Hauske, Sibylle J.
  • Erschienen: Hindawi Limited, 2017
  • Erschienen in: Journal of Diabetes Research, 2017 (2017), Seite 1-11
  • Sprache: Englisch
  • DOI: 10.1155/2017/9506730
  • ISSN: 2314-6745; 2314-6753
  • Schlagwörter: Endocrinology ; Endocrinology, Diabetes and Metabolism
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Considering that the homozygous <jats:italic>CNDP1</jats:italic> (CTG)<jats:sub>5</jats:sub> genotype affords protection against diabetic nephropathy (DN) in female patients with type 2 diabetes, this study assessed if this association remains gender-specific when applying clinical inclusion criteria (CIC-DN) or biopsy proof (BP-DN). Additionally, it assessed if the prevalence of the protective genotype changes with diabetes duration and time on hemodialysis and if this occurs in association with serum carnosinase (CN-1) activity. Whereas the distribution of the (CTG)<jats:sub>5</jats:sub> homozygous genotype in the no-DN and CIC-DN patients was comparable, a lower frequency was found in the BP-DN patients, particularly in females. We observed a significant trend towards high frequencies of the (CTG)<jats:sub>5</jats:sub> homozygous genotype with increased time on dialysis. This was also observed for diabetes duration but only reached significance when both (CTG)<jats:sub>5</jats:sub> homo- and heterozygous patients were included. CN-1 activity negatively correlated with time on hemodialysis and was lower in (CTG)<jats:sub>5</jats:sub> homozygous patients. The latter remained significant in female subjects after gender stratification. We confirm the association between the <jats:italic>CNDP1</jats:italic> genotype and DN to be likely gender-specific. Although our data also suggest that (CTG)<jats:sub>5</jats:sub> homozygous patients may have a survival advantage on dialysis and in diabetes, this hypothesis needs to be confirmed in a prospective cohort study.</jats:p>
  • Zugangsstatus: Freier Zugang