> Detailanzeige

Dimić, Dušan S.; Marković, Zoran S.; Saso, Luciano; Avdović, Edina H.; Đorović, Jelena R.; Petrović, Isidora P.; Stanisavljević, Danijela D.; Stevanović, Milena J.; Potočňák, Ivan; Samoľová, Erika; Trifunović, Srećko R.; Dimitrić Marković, Jasmina M.

Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent
  • Beteiligte: Dimić, Dušan S.; Marković, Zoran S.; Saso, Luciano; Avdović, Edina H.; Đorović, Jelena R.; Petrović, Isidora P.; Stanisavljević, Danijela D.; Stevanović, Milena J.; Potočňák, Ivan; Samoľová, Erika; Trifunović, Srećko R.; Dimitrić Marković, Jasmina M.
  • Erschienen: Hindawi Limited, 2019
  • Erschienen in: Oxidative Medicine and Cellular Longevity
  • Sprache: Englisch
  • DOI: 10.1155/2019/2069250
  • ISSN: 1942-0900; 1942-0994
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione, was completely structurally characterized by X-ray crystallography. It was shown that several types of hydrogen bonds are present, which additionally stabilize the structure. The compound was tested <jats:italic>in vitro</jats:italic> against different cell lines, healthy human keratinocyte HaCaT, cervical squamous cell carcinoma SiHa, breast carcinoma MCF7, and hepatocellular carcinoma HepG2. Compared to control, the new derivate showed a stronger effect on both healthy and carcinoma cell lines, with the most prominent effect on the breast carcinoma MCF7 cell line. The molecular docking study, obtained for ten different conformations of the new compound, showed its inhibitory nature against CDK<jats:sub>S</jats:sub> protein. Lower inhibition constant, relative to one of 4-OH-coumarine, proved stronger and more numerous interactions with CDK<jats:sub>S</jats:sub> protein. These interactions were carefully examined for both parent molecule and derivative and explained from a structural point of view.</jats:p>
  • Zugangsstatus: Freier Zugang