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Medientyp:
E-Artikel
Titel:
Cyclodextrin-Containing Polymers: Versatile Platforms of Drug Delivery Materials
Beteiligte:
Heidel, Jeremy D.;
Schluep, Thomas
Erschienen:
Hindawi Limited, 2012
Erschienen in:Journal of Drug Delivery
Sprache:
Englisch
DOI:
10.1155/2012/262731
ISSN:
2090-3014;
2090-3022
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>Nanoparticles are being widely explored as potential therapeutics for numerous applications in medicine and have been shown to significantly improve the circulation, biodistribution, efficacy, and safety profiles of multiple classes of drugs. One leading class of nanoparticles involves the use of linear, cyclodextrin-containing polymers (CDPs). As is discussed in this paper, CDPs can incorporate therapeutic payloads into nanoparticles via covalent attachment of prodrug/drug molecules to the polymer (the basis of the Cyclosert platform) or by noncovalent inclusion of cationic CDPs to anionic, nucleic acid payloads (the basis of the RONDEL platform). For each of these two approaches, we review the relevant molecular architecture and its rationale, discuss the physicochemical and biological properties of these nanoparticles, and detail the progress of leading drug candidates for each that have achieved clinical evaluation. Finally, we look ahead to potential future directions of investigation and product candidates based upon this technology.</jats:p>