Beschreibung:
<jats:p><jats:italic>Introduction</jats:italic>. This study aimed to evaluate whether Onco<jats:italic>type</jats:italic>Dx test results predict receipt of adjuvant chemotherapy in breast cancer patients who received an Onco<jats:italic>type</jats:italic>Dx recurrence score (RS).<jats:italic>Materials and Methods</jats:italic>. Pathology records were used to identify breast cancer patients who had Onco<jats:italic>type</jats:italic>Dx testing between December 2004 and January 2009 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>118</mml:mn></mml:mrow></mml:math>). Patient sociodemographic information, tumor characteristics, RS, and treatment-specific data were collected via chart review. RS was classified as follows: low (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mtext>RS</mml:mtext><mml:mo>≤</mml:mo><mml:mn>17</mml:mn></mml:mrow></mml:math>), intermediate (RS = 18–30), or high (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:mtext>RS</mml:mtext><mml:mo>≥</mml:mo><mml:mn>31</mml:mn></mml:mrow></mml:math>). Bivariate analyses were conducted to investigate the relationship between adjuvant chemotherapy receipt and each sociodemographic and clinical characteristic; significant sociodemographic and clinical variables were included in a multivariable logistic regression model.<jats:italic>Results</jats:italic>. In multivariable analysis controlling for tumor size, histologic grade, and nuclear grade, only RS remained significantly associated with chemotherapy uptake. Relative to low RS, an intermediate (adjusted odds ratio [AOR], 21.24; 95% confidence interval [CI], 3.62–237.52) or high (AOR, 15.07; 95% CI, 1.28–288.21) RS was associated with a greater odds of chemotherapy uptake.<jats:italic>Discussion</jats:italic>. Results indicate that RS was significantly associated with adjuvant chemotherapy uptake, suggesting that Onco<jats:italic>type</jats:italic>Dx results were used to inform treatment decision making, although it is unclear if and how the information was conveyed to patients.</jats:p>