Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Motor Deficits Are Produced By Removing Some Cortical TransplantsGrafted Into Injured Sensorimotor Cortexof Neonatal Rats
Beteiligte:
Sandor, Rick;
Gonzalez, Manuel F.;
Moseley, Michael;
Sharp, Frank R.
Erschienen:
Wiley, 1991
Erschienen in:
Neural Plasticity, 2 (1991) 3-4, Seite 221-233
Sprache:
Englisch
DOI:
10.1155/np.1991.221
ISSN:
2090-5904;
1687-5443
Entstehung:
Anmerkungen:
Beschreibung:
Fetal frontal cortex was transplanted into cavities formed in the right, motor cortex of neonatal rats. As adults, the animals were trained to press two levers in rapid succession with their left forelimb to receive food rewards. Once they had reached an optimal level of performance, the effect of removing their transplants was assessed. Surgical removal of transplants significantly impaired the performance of 2 of 4 subjects. Placing a crossstrain skin graft to induce the immunological rejection of the transplants produced a behavioral deficit in 1 of 2 subjects with complete transplant removal. Skin grafts produced no behavioral effects in four subjects that had surviving transplants. Since the motor deficit produced by transplant removal resembled those observed following the removal of normal motor cortex, we propose that these three transplants functioned within the host brain.Histology Showed that the procedures used to remove cortical grafts did not injure any host brains. Therefore, host brain damage is unlikely to account for the behavioral deterioration that followed transplant removals.