Erschienen in:Journal of Biomedicine and Biotechnology
Sprache:
Englisch
DOI:
10.1155/s1110724304403106
ISSN:
1110-7243;
1110-7251
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>In a comparative study, 9 healthy volunteers ingested a single oral dose of 400 mL red grape juice or red wine with dose-adjusted anthocyanin content (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="$283.5$"><mml:mrow><mml:mn>283.5</mml:mn></mml:mrow></mml:math>mg or<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="$279.6$"><mml:mrow><mml:mn>279.6</mml:mn></mml:mrow></mml:math>mg, resp.) in crossover. The content of anthocyanin glucosides was detected in plasma and urinary excretion. Additionally, the plasmatic antioxidant activity was assessed after intake. Based on the plasma content, biokinetic criteria of the single anthocyanins were calculated, such as AUC,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="$\mathrm{c}_{\mathrm{max}}$"><mml:mrow><mml:msub><mml:mtext>c</mml:mtext><mml:mrow><mml:mtext>max</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="$\mathrm{t}_{\mathrm{max}}$"><mml:mrow><mml:msub><mml:mtext>t</mml:mtext><mml:mrow><mml:mtext>max</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>, and the elimination rate<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="$\mathrm{t}_{1/2}$"><mml:mrow><mml:msub><mml:mtext>t</mml:mtext><mml:mrow><mml:mrow><mml:mtext>1</mml:mtext><mml:mo>/</mml:mo><mml:mn>2</mml:mn></mml:mrow></mml:mrow></mml:msub></mml:mrow></mml:math>. The urinary excretion of total anthocyanins differed significantly and amounted to<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="$0.18$"><mml:mrow><mml:mn>0.18</mml:mn></mml:mrow></mml:math>% (red wine) and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="$0.23$"><mml:mrow><mml:mn>0.23</mml:mn></mml:mrow></mml:math>% (red grape juice) of the administered dose. Additionally, the plasmatic antioxidant activity increased to higher levels after juice ingestion compared to wine. The intestinal absorption of the anthocyanins of red grape juice seemed to be improved compared to red wine, suggesting a possible synergistic effect of the glucose content of the juice. The improved absorption resulted in an enhanced plasmatic bioactivity.</jats:p>