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George, Stephanie M.; Ballard-Barbash, Rachel; Shikany, James M.; Caan, Bette J.; Freudenheim, Jo L.; Kroenke, Candyce H.; Vitolins, Mara Z.; Beresford, Shirley A.; Neuhouser, Marian L.

Better Postdiagnosis Diet Quality Is Associated with Reduced Risk of Death among Postmenopausal Women with Invasive Breast Cancer in the Women's Health Initiative

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  • Medientyp: E-Artikel
  • Titel: Better Postdiagnosis Diet Quality Is Associated with Reduced Risk of Death among Postmenopausal Women with Invasive Breast Cancer in the Women's Health Initiative
  • Beteiligte: George, Stephanie M.; Ballard-Barbash, Rachel; Shikany, James M.; Caan, Bette J.; Freudenheim, Jo L.; Kroenke, Candyce H.; Vitolins, Mara Z.; Beresford, Shirley A.; Neuhouser, Marian L.
  • Erschienen: American Association for Cancer Research (AACR), 2014
  • Erschienen in: Cancer Epidemiology, Biomarkers & Prevention
  • Sprache: Englisch
  • DOI: 10.1158/1055-9965.epi-13-1162
  • ISSN: 1055-9965; 1538-7755
  • Schlagwörter: Oncology ; Epidemiology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:p>Background: Few studies have evaluated whether adherence to dietary recommendations is associated with mortality among cancer survivors. In breast cancer survivors, we examined how postdiagnosis Healthy Eating Index (HEI)-2005 scores were associated with all-cause and cause-specific mortality.</jats:p> <jats:p>Methods: Our prospective cohort study included 2,317 postmenopausal women, ages 50 to 79 years, in the Women's Health Initiative's Dietary Modification Trial (n = 1,205) and Observational Study (n = 1,112), who were diagnosed with invasive breast cancer and completed a food frequency questionnaire after being diagnosed. We followed women from this assessment forward. We used Cox proportional hazards models to estimate multivariate-adjusted HRs and 95% confidence intervals (CI) for death from any cause, breast cancer, and causes other than breast cancer, according to HEI-2005 quintiles.</jats:p> <jats:p>Results: Over 9.6 years, 415 deaths occurred. After adjustment for key covariates, women consuming better quality diets had a 26% lower risk of death from any cause (HRQ4:Q1, 0.74; 95% CI, 0.55–0.99; Ptrend = 0.043) and a 42% lower risk of death from non–breast cancer causes (HRQ4:Q1, 0.58; 95% CI, 0.38–0.87; Ptrend = 0.011). HEI-2005 score was not associated with breast cancer death (HRQ4:Q1, 0.91; 95% CI, 0.60–1.40; Ptrend = 0.627). In analyses stratified by tumor estrogen receptor (ER) status, better diet quality was associated with a reduced risk of all-cause mortality among women with ER+ tumors (n = 1,758; HRQ4:Q1, 0.55; 95% CI, 0.38–0.79; Ptrend = 0.0009).</jats:p> <jats:p>Conclusion: Better postdiagnosis diet quality was associated with reduced risk of death, particularly from non–breast cancer causes.</jats:p> <jats:p>Impact: Breast cancer survivors may experience improved survival by adhering to U.S. dietary guidelines. Cancer Epidemiol Biomarkers Prev; 23(4); 575–83. ©2014 AACR.</jats:p>
  • Zugangsstatus: Freier Zugang