Lemoine, Antoinette;
Saffroy, Raphael;
Bosselut, Nelly;
Lecorche, Emmanuel;
Etessami, Reza;
Allard, Marc A.;
Tredaniel, Jean;
Balaton, Andre;
Validire, Pierre;
Morere, Jean F.
Abstract 2231: The prevalence of EGFR and KRAS mutations in a population of African immigrants in France is closer to that of Asian populations than to white Europeans
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Medientyp:
E-Artikel
Titel:
Abstract 2231: The prevalence of EGFR and KRAS mutations in a population of African immigrants in France is closer to that of Asian populations than to white Europeans
Beteiligte:
Lemoine, Antoinette;
Saffroy, Raphael;
Bosselut, Nelly;
Lecorche, Emmanuel;
Etessami, Reza;
Allard, Marc A.;
Tredaniel, Jean;
Balaton, Andre;
Validire, Pierre;
Morere, Jean F.
Erschienen:
American Association for Cancer Research (AACR), 2014
Beschreibung:
<jats:title>Abstract</jats:title>
<jats:p>The choice of treatment for patients with NSCLC relies on the EGFR and KRAS mutational status. Previous studies have reported differences in prevalence of mutations between Asiatics, Hispanics and Caucasians. However, there is few data with respect to the frequencies of EGFR and KRAS mutations in patients originated from Africa, who represent the largest immigrant population in France.</jats:p>
<jats:p>Between May 2011 and November 2013, a mutational analysis for KRAS and EGRF has been performed in tumor samples from 1,973 consecutive patients with NSCLC at a single oncogenetic platform. Demographic and clinical data of all these patients were extracted from their electronic medical record and analyzed.</jats:p>
<jats:p>Our study population included 1,739 (88%) white Europeans, 204 (10%) patients from Africa and 30 (2%) patients from Asia (mostly from Vietnam or Cambodge).</jats:p>
<jats:p>As expected, the higher prevalence of EGFR mutations was found in Asiatic women (50%), the lower was observed in Caucasian women population (17%, p&lt;0.001). This low frequency of EGFR mutations has already been reported in other European populations. Surprisingly, EGFR mutations rate was as high as 32% in African women patients (p&lt;0.001), whereas African men exhibited a very low frequency of EGFR mutations (5%, p&lt;0.001) as well as the French non immigrant patients (6%).</jats:p>
<jats:p>KRAS mutation rate was higher among white European (26%) than Asiatic (10%) or African (10%) patients. Although KRAS mutation rate did not differ by sex in white Europeans (men 25% versus women 27%, respectively), it was 3 fold more frequent in men than in women among African (19% versus 5%, respectively, p&lt;0.001) and Asiatic patients.Therefore EGFR or KRAS mutation rates in African immigrant population in France are closer to those observed in Asians or even Hispanics, than in Caucasians. These frequencies also differ from those reported in African Americans. The ancestral and recent migration of populations as well as social habits could explain these results.</jats:p>
<jats:p>Citation Format: Antoinette Lemoine, Raphael Saffroy, Nelly Bosselut, Emmanuel Lecorche, Reza Etessami, Marc A. Allard, Jean Tredaniel, Andre Balaton, Pierre Validire, Jean F. Morere. The prevalence of EGFR and KRAS mutations in a population of African immigrants in France is closer to that of Asian populations than to white Europeans. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2231. doi:10.1158/1538-7445.AM2014-2231</jats:p>