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Chan, Jason Earl; Marjanovic, Nemanja Despot; Hofree, Matan; Canner, David; Wu, Katherine; Hartmann, Griffin; Smith, Olivia C.; Kim, Jonathan; Hudson, Anna; Subramanian, Ayshwarya; Pitter, Kenneth; Rekhtman, Natasha; Massion, Pierre P.; Poirier, John T.; Rudin, Charles M.; Jacks, Tyler; Regev, Aviv; Tammela, Tuomas

Abstract 1511: A highly plastic cell state emerges during lung adenocarcinoma evolution

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  • Medientyp: E-Artikel
  • Titel: Abstract 1511: A highly plastic cell state emerges during lung adenocarcinoma evolution
  • Beteiligte: Chan, Jason Earl; Marjanovic, Nemanja Despot; Hofree, Matan; Canner, David; Wu, Katherine; Hartmann, Griffin; Smith, Olivia C.; Kim, Jonathan; Hudson, Anna; Subramanian, Ayshwarya; Pitter, Kenneth; Rekhtman, Natasha; Massion, Pierre P.; Poirier, John T.; Rudin, Charles M.; Jacks, Tyler; Regev, Aviv; Tammela, Tuomas
  • Erschienen: American Association for Cancer Research (AACR), 2020
  • Erschienen in: Cancer Research
  • Sprache: Englisch
  • DOI: 10.1158/1538-7445.am2020-1511
  • ISSN: 0008-5472; 1538-7445
  • Schlagwörter: Cancer Research ; Oncology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:p>The role of tumor heterogeneity in the progression of lung adenocarcinoma remains poorly understood. In order to understand how tumor heterogeneity impacts tumor evolution, we profiled single cell transcriptomes from genetically engineered mouse lung tumors at various stages. We observed a set of reproducible transcriptional states whose diversity increased over time. Additionally, we identified a highly plastic cell state that arose in every tumor we obtained. We profiled this cell state and identified a robust potential for phenotypic switching, an increased potential for spheroid formation in tumor sphere cultures, and an enrichment of the highly plastic cell state after chemotherapeutic stress in vivo. Our work suggests that the highly plastic cell state plays a significant role, and perhaps even drives, tumor progression and resistance to therapy in lung adenocarcinoma.</jats:p> <jats:p>Citation Format: Jason Earl Chan, Nemanja Despot Marjanovic, Matan Hofree, David Canner, Katherine Wu, Griffin Hartmann, Olivia C. Smith, Jonathan Kim, Anna Hudson, Ayshwarya Subramanian, Kenneth Pitter, Natasha Rekhtman, Pierre P. Massion, John T. Poirier, Charles M. Rudin, Tyler Jacks, Aviv Regev, Tuomas Tammela. A highly plastic cell state emerges during lung adenocarcinoma evolution [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 1511.</jats:p>
  • Zugangsstatus: Freier Zugang