> Detailanzeige

Visvanathan, Kala; Shaw, Patricia; May, Betty J.; Bahadirli-Talbott, Asli; Kaushiva, Alpana; Risch, Harvey; Narod, Steven; Wang, Tian-Li; Parkash, Vinita; Vang, Russell; Levine, Douglas A.; Soslow, Robert; Kurman, Robert; Shih, Ie-Ming

Fallopian Tube Lesions in Women at High Risk for Ovarian Cancer: A Multicenter Study

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Fallopian Tube Lesions in Women at High Risk for Ovarian Cancer: A Multicenter Study
  • Beteiligte: Visvanathan, Kala; Shaw, Patricia; May, Betty J.; Bahadirli-Talbott, Asli; Kaushiva, Alpana; Risch, Harvey; Narod, Steven; Wang, Tian-Li; Parkash, Vinita; Vang, Russell; Levine, Douglas A.; Soslow, Robert; Kurman, Robert; Shih, Ie-Ming
  • Erschienen: American Association for Cancer Research (AACR), 2018
  • Erschienen in: Cancer Prevention Research, 11 (2018) 11, Seite 697-706
  • Sprache: Englisch
  • DOI: 10.1158/1940-6207.capr-18-0009
  • ISSN: 1940-6215; 1940-6207
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Abstract The prognosis of women diagnosed with invasive high-grade serous ovarian carcinoma (HGSC) is poor. More information about serous tubal intraepithelial carcinoma (STIC) and serous tubal intraepithelial lesions (STIL), putative precursor lesions of HGSC, could inform prevention efforts. We conducted a multicenter study to identify risk/protective factors associated with STIC/STILs and characterize p53 signatures in the fallopian tube. The fallopian tubes and ovaries of 479 high-risk women ≥30 years of age who underwent bilateral risk-reducing salpingo-oophorectomy were reviewed for invasive cancer/STICs/STILs. Epidemiologic data was available for 400 of these women. In 105 women, extensive sampling of the tubes for STICs/STILs/p53 signatures were undertaken. Descriptive statistics were used to compare groups with and without lesions. The combined prevalence of unique tubal lesions [invasive serous cancer (n = 6) /STICs (n = 14)/STILs (n = 5)] was 6.3% and this was split equally among BRCA1 (3.0%) and BRCA2 mutation carriers (3.3%). A diagnosis of invasive cancer was associated with older age but no risk/protective factor was significantly associated with STICs/STILs. Extensive sampling identified double the number of STICs/STILs (11.9%), many p53 signatures (27.0%), and multiple lesions in 50% of the cases. Women with p53 signatures in the fimbria were older than women with signatures in the remaining tube (P = 0.03). STICs/STILs may not share the protective factors that are associated with HGSC. It is plausible that these factors are only associated with STICs that progress to HGSC. Having multiple lesions in the fimbria may be an important predictor of disease progression. Cancer Prev Res; 11(11); 697–706. ©2018 AACR.
  • Zugangsstatus: Freier Zugang