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Sener Dinc, Nur; Aydın, Kubra; Odabas, Hatice; Ercelep, Ozlem; Tufan, Gulnihal; Seker, Mesut; Yasar, Nurgul; Aydin, Dincer; Yuksel, Sinemis; Mert, Aslihan; Ozcelik, Melike; Korkmaz, Taner; Yildiz, Ramazan; Aliustaoglu, Mehmet; Mayadagli, Alpaslan; Dane, Faysal; Gumus, Mahmut

Pretreatment PET/CT Standardized Uptake Values Play a Role in Predicting Response to Treatment and Survival in Patients with Small Cell Lung Cancer

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  • Medientyp: E-Artikel
  • Titel: Pretreatment PET/CT Standardized Uptake Values Play a Role in Predicting Response to Treatment and Survival in Patients with Small Cell Lung Cancer
  • Beteiligte: Sener Dinc, Nur; Aydın, Kubra; Odabas, Hatice; Ercelep, Ozlem; Tufan, Gulnihal; Seker, Mesut; Yasar, Nurgul; Aydin, Dincer; Yuksel, Sinemis; Mert, Aslihan; Ozcelik, Melike; Korkmaz, Taner; Yildiz, Ramazan; Aliustaoglu, Mehmet; Mayadagli, Alpaslan; Dane, Faysal; Gumus, Mahmut
  • Erschienen: S. Karger AG, 2016
  • Erschienen in: Oncology Research and Treatment
  • Sprache: Englisch
  • DOI: 10.1159/000444272
  • ISSN: 2296-5270; 2296-5262
  • Schlagwörter: Cancer Research ; Oncology ; Hematology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; We investigated the role of standardized uptake values (SUVs) of the primary tumor in small cell lung cancer (SCLC) patients. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;/i&gt;&lt;/b&gt; The relationship between SUV and response to treatment was investigated using receiver operating characteristic (ROC) curve analysis, and the efficient cut-off value for detecting response to treatment was determined. The effects of SUV on response to treatment and survival were investigated. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; 90 patients with a median age of 58 years (range 39-83 years) were included. Median follow-up was 11 months. The suitable cut-off SUV for determination of response was found to be 10 in ROC analysis. The sensitivity and specificity of this value were 85.7% (95% confidence interval (95% CI) 63-96) and 61.8% (95% CI 49-73) (area under the curve 0.783; p = 0.0001), respectively. The overall objective response rate in patients with involvement above the cut-off value was 93.3% compared to 59.1% in those with involvement below the cut-off value (p &lt; 0.0001). In uni- and multivariate analysis, favorable effects of limited-stage disease on response to treatment were established (p &lt; 0.05). The effect of an SUV higher than the cut-off value on progression-free survival was borderline (p = 0.085). &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; These data may contribute to identifying prognostic disease characteristics and response to treatment.</jats:p>