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Medientyp:
E-Artikel
Titel:
Cerebrospinal Fluid Findings in Neurological Diseases Associated with Sjögren's Syndrome
Beteiligte:
Pars, Kaweh;
Pul, Refik;
Schwenkenbecher, Philipp;
Sühs, Kurt-Wolfram;
Wurster, Ulrich;
Witte, Torsten;
Bronzlik, Paul;
Stangel, Martin;
Skripuletz, Thomas
Erschienen:
S. Karger AG, 2017
Erschienen in:
European Neurology, 77 (2017) 1-2, Seite 91-102
Sprache:
Englisch
DOI:
10.1159/000454765
ISSN:
0014-3022;
1421-9913
Entstehung:
Anmerkungen:
Beschreibung:
<b><i>Background:</i></b> Sjögren's syndrome is a chronic autoimmune-mediated disease that can cause a variety of neurological manifestations. <b><i>Methods:</i></b> This study investigated characteristics of clinical and cerebrospinal fluid (CSF) features in patients with neurological diseases associated with Sjögren's syndrome. Eighty-two patients were examined separately according to the presence of Sjögren's syndrome alone or in combination with other autoimmune diseases. <b><i>Results:</i></b> In the 47 patients with primary Sjögren's syndrome, peripheral neuropathy (57%) was found most frequently, followed by the involvement of the central nervous system (CNS; 17%), cranial neuropathy (15%), and myalgia (11%). These patients did not display consistent signs of inflammation in the CSF. Slight pleocytosis of 8-107 cells/µL was found in patients with peripheral neuropathy (9%), cranial neuropathy (20%), and CNS involvement (25%). Oligoclonal bands indicating intrathecal IgG synthesis occurred in 26% of patients with peripheral neuropathy, 20% of patients with cranial neuropathy, and 25% of patients with CNS involvement. <b><i>Conclusions:</i></b> In patients with Sjögren's syndrome and neurological manifestations, inflammatory CSF changes were rarely found and did not show a characteristic pattern irrespective of peripheral or central genesis of neurological deficits. Analysis of the CSF presents therefore an important diagnostic procedure to exclude other autoimmune and infectious diseases.