Erschienen in:
Oncology Research and Treatment, 40 (2017) 5, Seite 294-297
Sprache:
Englisch
DOI:
10.1159/000464353
ISSN:
2296-5270;
2296-5262
Entstehung:
Anmerkungen:
Beschreibung:
The programmed cell death-1 receptor (PD-1) is an immune checkpoint inhibitor which is expressed on the surface of immune effector cells. It is activated mainly by PD-L1 which can be expressed by all human cells. The PD-1/PD-L1 pathway plays a subtle role in maintaining peripheral T-lymphocyte tolerance and regulating inflammation. In cancer, the expression of PD-L1 seems to be one of the major immune escape mechanisms. Many studies have shown efficacy of blocking PD-1 or PD-L1 with specific antibodies like pembrolizumab or atezulizumab. In breast cancer, potential response was demonstrated in metastatic triple-negative breast cancers.