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Farioli, Laura; Losappio, Laura Michelina; Giuffrida, Maria Gabriella; Pravettoni, Valerio; Micarelli, Gianluigi; Nichelatti, Michele; Scibilia, Joseph; Mirone, Corrado; Cavallarin, Laura; Lamberti, Cristina; Balossi, Luca Giuseppe; Pastorello, Elide Anna

Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy

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  • Medientyp: E-Artikel
  • Titel: Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy
  • Beteiligte: Farioli, Laura; Losappio, Laura Michelina; Giuffrida, Maria Gabriella; Pravettoni, Valerio; Micarelli, Gianluigi; Nichelatti, Michele; Scibilia, Joseph; Mirone, Corrado; Cavallarin, Laura; Lamberti, Cristina; Balossi, Luca Giuseppe; Pastorello, Elide Anna
  • Erschienen: S. Karger AG, 2017
  • Erschienen in: International Archives of Allergy and Immunology
  • Sprache: Englisch
  • DOI: 10.1159/000481985
  • ISSN: 1018-2438; 1423-0097
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at issue is which in vivo and/or in vitro tests (food challenge, component-resolved diagnosis, house dust mite [HDM] sensitization) can help in distinguishing shrimp-allergic subjects from subjects that are sensitized but tolerant. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; The aim of this study was to evaluate the role of IgE to the different shrimp and mite allergens in distinguishing shrimp challenge-positive from challenge-negative patients. Subjects with suspected hypersensitivity reactions to shrimp, positive skin prick tests (SPTs), and/or anti-shrimp IgE were submitted to open and double-blind placebo-controlled food challenges (DBPCFC). Specific IgE to shrimp, mites, and the recombinants rPen a 1, rDer p 1, 2, and 10 were tested using ImmunoCAP-FEIA. IgE immunoblotting was performed to identify the patients' allergenic profiles. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; In total, 13 out of 51 (25.5%) patients with reported reactions to shrimp were truly shrimp&lt;b&gt; &lt;/b&gt;allergic (7 DBPCFC positive and 6 with documented severe reactions). These patients had significantly higher skin test wheal diameters&lt;b&gt; &lt;/b&gt;than nonallergic patients,&lt;b&gt; &lt;/b&gt;as well as higher levels of IgE to rPen a 1 and rDer p 10. HDM-induced asthma and the&lt;b&gt; &lt;/b&gt;simultaneous presence of anti-nDer p 1, 2, and 10 IgE levels increased the risk of true shrimp allergy. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Food challenge tests are mandatory for the diagnosis of shrimp allergy. Tropomyosin is associated with clinical reactivity. HDM-induced asthma and anti-mite IgE are risk factors for shrimp allergy.</jats:p>