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Medientyp:
E-Artikel
Titel:
B Cell-Based Cancer Immunotherapy
Beteiligte:
Wennhold, Kerstin;
Shimabukuro-Vornhagen, Alexander;
von Bergwelt-Baildon, Michael
Erschienen:
S. Karger AG, 2019
Erschienen in:Transfusion Medicine and Hemotherapy
Sprache:
Englisch
DOI:
10.1159/000496166
ISSN:
1660-3796;
1660-3818
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>B cells are not only producers of antibodies, but also contribute to immune regulation or act as potent antigen-presenting cells. The potential of B cells for cellular therapy is still largely underestimated, despite their multiple diverse effector functions. The CD40L/CD40 signaling pathway is the most potent activator of antigen presentation capacity in B lymphocytes. CD40-activated B cells are potent antigen-presenting cells that induce specific T-cell responses in vitro and in vivo. In preclinical cancer models in mice and dogs, CD40-activated B cell-based cancer immunotherapy was able to induce effective antitumor immunity. So far, there have been only few early-stage clinical studies involving B cell-based cancer vaccines. These trials indicate that B cell-based immunotherapy is generally safe and associated with little toxicity. Furthermore, these studies suggest that B-cell immunotherapy can elicit antitumor T-cell responses. Alongside the recent advances in cellular therapies in general, major obstacles for generation of good manufacturing practice-manufactured B-cell immunotherapies have been overcome. Thus, a first clinical trial involving CD40-activated B cells might be in reach.</jats:p>