Erschienen in:
Case Reports in Nephrology and Dialysis, 9 (2019) 3, Seite 149-157
Sprache:
Englisch
DOI:
10.1159/000503951
ISSN:
2296-9705
Entstehung:
Hochschulschrift:
Anmerkungen:
Beschreibung:
<jats:p>We report the effectiveness of daratumumab, a human IgGκ monoclonal antibody targeting CD38 on plasma cells, for therapy-refractory antibody-mediated rejection (AMR) due to blood group antibodies in a 59-year-old man who received a living ABO-incompatible kidney transplantation. Standard treatment options for AMR due to blood group antibodies including immunoadsorption, lymphocyte depletion with anti-human T-lymphocyte globulins, intravenous methylprednisolone pulses and eculizumab limited tissue injury, however failed to sufficiently suppress blood group antibody production. After administration of daratumumab as a rescue therapy, blood group antibody titers decreased and remained at low levels without further immunoadsorption and allowed kidney graft function to recover.</jats:p>