> Detailanzeige

Quadrelli, Silvia A.; Roncoroni, Aquiles J.

Is Asthma in the Elderly Really Different?

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Is Asthma in the Elderly Really Different?
  • Beteiligte: Quadrelli, Silvia A.; Roncoroni, Aquiles J.
  • Erschienen: S. Karger AG, 1998
  • Erschienen in: Respiration, 65 (1998) 5, Seite 347-353
  • Sprache: Englisch
  • DOI: 10.1159/000029294
  • ISSN: 0025-7931; 1423-0356
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: To examine the nature of asthma in the elderly, we compared older (group 1: 65 years or older, n = 50) with younger patients (group 2: <40 years, n = 99) and to determine the influence of long-standing disease, elderly asthmatics with early onset (group A: onset before 40, n = 22) were compared with patients developing symptoms later in their lives (group B: onset after 40, n = 22). Blood eosinophilia and IgE value ≥100 IU/l were more frequent in younger patients. Short symptom-free periods were more frequent among older asthmatics (78.5 vs. 45.4%, p < 0.001). Only 31.2% of older patients had only mild symptoms. Requirement of systemic steroids was higher in the elderly population. The worst FEV<sub>1</sub> was lower in older patients (54.4 ± 17.3 vs. 71.8 ± 18.5%, p {FC96}& 0.001). Patients with early-onset asthma showed more frequently shorter symptom-free periods (93.3 vs. 53.3%, p <0.05), higher emergency admissions/year, and hospitalizations/year. Best FEV<sub>1</sub> (group 1: 66.7 ± 13.7% vs. group 2: 90.3 ± 15.1%, p < 0.005) and worst FEV<sub>1</sub> (46.2 ± 13.1 vs. 61.0 ± 13.2%, p < 0.01) were lower in early-onset patients. A higher systemic steroid requirement, a lower best and worst FEV<sub>1</sub>, shorter symptom-free periods and a lesser proportion of patients with only mild symptoms were observed in patients older than 65 with early-onset asthma compared with those younger than 40 years. Elderly patients with a shorter duration of asthma were not different from young patients. Our study strongly suggests that severity of asthma and development of irreversible airflow obstruction depend on the duration of disease.