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Heiden, Angela; Schüssler, Petra; Itzlinger, Ulrike; Leisch, Friedrich; Scharfetter, Joachim; Gebhardt, Christian; Fuchs, Karoline; Willeit, Matthäus; Nilsson, Linda; Miller-Reiter, Ellenore; Stompe, Thomas; Meszaros, Kurt; Sieghart, Werner; Hornik, Kurt; Kasper, Siegfried; Aschauer, Harald N.

Association Studies of Candidate Genes in Bipolar Disorders

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  • Medientyp: E-Artikel
  • Titel: Association Studies of Candidate Genes in Bipolar Disorders
  • Beteiligte: Heiden, Angela; Schüssler, Petra; Itzlinger, Ulrike; Leisch, Friedrich; Scharfetter, Joachim; Gebhardt, Christian; Fuchs, Karoline; Willeit, Matthäus; Nilsson, Linda; Miller-Reiter, Ellenore; Stompe, Thomas; Meszaros, Kurt; Sieghart, Werner; Hornik, Kurt; Kasper, Siegfried; Aschauer, Harald N.
  • Erschienen: S. Karger AG, 2000
  • Erschienen in: Neuropsychobiology, 42 (2000) Suppl. 1, Seite 18-21
  • Sprache: Englisch
  • DOI: 10.1159/000054846
  • ISSN: 1423-0224; 0302-282X
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: The aim of the investigation was to test genes for predisposition to bipolar affective disorder. Therefore, we studied candidate genes in a sample of unrelated patients (n = 102) and healthy controls (n = 79) of Austrian origin, searching for a possible association between polymorphic DNA markers of 5 candidate genes (serotonin transporter,<i> 5-HTT;</i> serotonin 2a receptor, <i>5-HT2a;</i> dopamine D2 receptor, <i>DRD2; </i>dopamine D3 receptor, <i>DRD3;</i> dopamine transporter, <i>DAT1</i>) and bipolar disorder. There was an association between allelic and genotypic frequencies of <i>5-HTT</i> and affection status (p = 0.014 and p = 0.017, respectively). However, after correction for multiple comparisons (Bonferroni), these results did not remain significant. Nevertheless, the findings might suggest that alterations in the structure of <i>5-HTT</i> are involved in the pathogenesis of bipolar disorder, which could have major implications in treatment. No association between <i>5-HT2a, DRD2, DRD3, DAT1</i> and bipolar disorder was found.