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Wolf, Cornelia E.; Haubelt, Hannelore; Pauer, Hans Ulrich; Hinney, Bernd; Krome-Cesar, Claudette; Legler, Tobias J.; Hellstern, Peter; Emons, Günter; Zoll, Barbara; Köhler, Michael

Recurrent Pregnancy Loss and Its Relation to FV Leiden, FII G20210A and Polymorphisms of Plasminogen Activator and Plasminogen Activator Inhibitor

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  • Medientyp: E-Artikel
  • Titel: Recurrent Pregnancy Loss and Its Relation to FV Leiden, FII G20210A and Polymorphisms of Plasminogen Activator and Plasminogen Activator Inhibitor
  • Beteiligte: Wolf, Cornelia E.; Haubelt, Hannelore; Pauer, Hans Ulrich; Hinney, Bernd; Krome-Cesar, Claudette; Legler, Tobias J.; Hellstern, Peter; Emons, Günter; Zoll, Barbara; Köhler, Michael
  • Erschienen: S. Karger AG, 2003
  • Erschienen in: Pathophysiology of Haemostasis and Thrombosis
  • Sprache: Englisch
  • DOI: 10.1159/000077821
  • ISSN: 1424-8832; 1424-8840
  • Schlagwörter: Physiology (medical) ; Hematology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Thrombophilic disorders and hypofibrinolysis were demonstrated to be risk factors in a majority of women with recurrent pregnancy loss (RPL) and infertility. We investigated the association of FV G1691A mutation, F II G20210A gene polymorphism (PM), 4G/5G PAI-1 and Alu I/D tPA PM in 32 women with infertility and 49 women with at least 2 unexplained early abortions. FV Leiden mutation was significantly more common in women with RPL (10%, p = 0.02) and infertility (19%, p = 0.0005) compared with controls (2%). PAI-1 4G PM and t-PA Alu I PM, alone or in combination, were not associated with RPL or infertility. 9/49 women with RPL showed coagulation disorders with heterozygous FV Leiden mutation (5), FXII (1), protein C (1) or protein S (2) deficiency. However, due to the small number of patients studied, no definite conclusion can be drawn.</jats:p>