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Anderson, Lisa J.; Westwood, Mark A.; Prescott, Emma; Walker, J. Malcolm; Pennell, Dudley J.; Wonke, Beatrix

Development of Thalassaemic Iron Overload Cardiomyopathy despite Low Liver Iron Levels and Meticulous Compliance to Desferrioxamine

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  • Medientyp: E-Artikel
  • Titel: Development of Thalassaemic Iron Overload Cardiomyopathy despite Low Liver Iron Levels and Meticulous Compliance to Desferrioxamine
  • Beteiligte: Anderson, Lisa J.; Westwood, Mark A.; Prescott, Emma; Walker, J. Malcolm; Pennell, Dudley J.; Wonke, Beatrix
  • Erschienen: S. Karger AG, 2006
  • Erschienen in: Acta Haematologica, 115 (2006) 1-2, Seite 106-108
  • Sprache: Englisch
  • DOI: 10.1159/000089475
  • ISSN: 0001-5792; 1421-9662
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: It is believed that myocardial iron deposition and the resultant cardiomyopathy only occur in the presence of severe liver iron overload. Using cardiovascular magnetic resonance, it is now possible to assess myocardial and liver iron levels as well as cardiac function in the same scan, allowing this supposition to be examined. We describe a patient with progressive myocardial iron deposition and the development of early iron overload cardiomyopathy despite excellent compliance to standard subcutaneous desferrioxamine, minimal liver iron and well-controlled serum ferritin levels. These indirect markers remained far below the thresholds conventionally believed to be associated with increased cardiac risk.