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Sperfeld, Anne-Dorte; Baumgartner, Annette; Kassubek, Jan

Magnetic Resonance Investigation of the Upper Spinal Cord in Pure and Complicated Hereditary Spastic Paraparesis

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  • Medientyp: E-Artikel
  • Titel: Magnetic Resonance Investigation of the Upper Spinal Cord in Pure and Complicated Hereditary Spastic Paraparesis
  • Beteiligte: Sperfeld, Anne-Dorte; Baumgartner, Annette; Kassubek, Jan
  • Erschienen: S. Karger AG, 2005
  • Erschienen in: European Neurology, 54 (2005) 4, Seite 181-185
  • Sprache: Englisch
  • DOI: 10.1159/000090294
  • ISSN: 0014-3022; 1421-9913
  • Entstehung:
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  • Beschreibung: Neuropathological studies of hereditary spastic paraparesis (HSP) have described axonal loss involving corticospinal and somatosensory tracts in the spinal cord. This MRI-based study was intended to investigate in vivo diameter alterations of the spinal cord in HSP, including both pure HSP (p-HSP, n = 20) and complicated HSP (c-HSP, n = 10). Standard MRI examinations of the cervical and thoracic spinal cord in HSP patients and a control group (n = 54) were analyzed by standardized spinal cord planimetry. In HSP patients, significant atrophy of the upper spinal cord compared to controls was observed at p<0.001 both at the cervical and at the thoracic level. Myelon diameters at both levels were also significantly reduced in the two HSP subgroups in an additional comparison with age-matched subgroups of controls each, but p-HSP and c-HSP groups themselves did not differ. Marked atrophy of the upper spinal cord seems to be associated with HSP, assumedly due to the central-distal axonopathy. However, the differences between p-HSP and c-HSP could not be visualized by structural MRI at spinal cord level.