Rifkin, Dena E.;
Katz, Ronit;
Fried, Linda F.;
Kestenbaum, Bryan;
Jenny, Nancy Swords;
Newman, Anne B.;
Siscovick, David S.;
Shlipak, Michael G.;
Sarnak, Mark J.
Association between Baseline Kidney Function and Change in CRP: An Analysis of the Cardiovascular Health Study
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Medientyp:
E-Artikel
Titel:
Association between Baseline Kidney Function and Change in CRP: An Analysis of the Cardiovascular Health Study
Beteiligte:
Rifkin, Dena E.;
Katz, Ronit;
Fried, Linda F.;
Kestenbaum, Bryan;
Jenny, Nancy Swords;
Newman, Anne B.;
Siscovick, David S.;
Shlipak, Michael G.;
Sarnak, Mark J.
Erschienen:
S. Karger AG, 2010
Erschienen in:
Nephron Clinical Practice, 115 (2010) 2, Seite c114-c121
Sprache:
Englisch
DOI:
10.1159/000312874
ISSN:
1660-2110
Entstehung:
Anmerkungen:
Beschreibung:
<i>Background:</i> In cross-sectional analyses, C-reactive protein (CRP) levels are inversely related to levels of kidney function. The relationship between kidney function and subsequent changes in CRP is unknown. <i>Methods:</i> We studied 4,364 individuals from the Cardiovascular Health Study, a longitudinal cohort of community-dwelling older adults. Baseline eGFRcys was estimated using cystatin C. CRP was measured at baseline and after 3 and 7 years of follow-up; slopes of change in CRP were calculated. <i>Results:</i> The mean (SD) age of the cohort was 72 (5.2) years; mean (SD) eGFRcys was 78.9 (18.4) ml/min/1.73 m<sup>2</sup>. The median (interquartile range IQR) baseline CRP was 2.39 (1.22, 4.33) mg/l; the median (IQR) yearly change in CRP was –0.0051 (–0.020 to 0.27) mg/l/year. After adjustment for demographic characteristics and the initial level of CRP, each standard deviation lower baseline eGFR was associated with a small and non-significant yearly increase in CRP (0.032 mg/l/year; 95% CI: –0.005 to 0.070, p = 0.094). <i>Conclusions:</i> We did not find a relationship between eGFR and subsequent changes in CRP. The association between kidney function and CRP in cross-sectional analyses may reflect unmeasured confounding by atherosclerosis; alternatively, the burden of comorbidity and interval mortality in this population may have masked a stronger longitudinal association between kidney function and change in CRP. Further study in younger populations may clarify whether impaired kidney function leads to change in inflammation over time.